Cefoperazone Induced
Gastrointestinal Bleeding
Published: August 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/19694.8316
Goutham Reddy Katukuri, Raja Naga Mahesh Maddala, Kusugodlu Ramamoorthi, Manjunatha Hande
1. Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital, Manipal, Udupi, Karnataka, India.
2. Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital, Manipal, Udupi, Karnataka, India.
3. Assistant Professor, Department of General Medicine, Kasturba Medical College, Kasturba Hospital, Manipal, Udupi, Karnataka, India.
4. Professor and HOD, Department of General Medicine, Kasturba Medical College, Kasturba Hospital, Manipal, Udupi, Karnataka, India.
Correspondence
Dr. Goutham Reddy Katukuri,
Flat no. 203, Shambavi Classic Apartments, Vidyaratna Nagar, Manipal, Udupi-576104, Karnataka, India.
E-mail: drgouthamreddy@yahoo.com
Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.
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